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Centre
for Integrative Physiology |
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| Gareth Leng |
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Centre
for Integrative Physiology |
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| Gareth Leng |
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CIP links:
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 Personal ProfileFrom 1977-1994 I was employed directly by the BBSRC at The Babraham Institute Cambridge. I moved to Edinburgh in November 1994 to the newly established Chair of Experimental Physiology. From 1996-2003 I was Editor-in-Chief of The Journal of Neuroendocrinology. I am currently an Editor of Neuroendocrinology and of Cognitive Processing, and am the Chair of the Programme Organising Committee for the 2010 World Congress of Neuroendocrinology. And a member of the executive committee of the International Neuroendocrine Federation. ResearchNeuronal networks in the hypothalamus, particularly those controlling pituitary hormone secretion and those controlling appetite and obesity. My research approach is multidisciplinary, including electrophysiology, molecular neuroanatomy, behavioural and functional studies and computational modelling.Funding
Team Members
Collaborations
Recent Publications2008 Leng G, Caquineau C, Ludwig M (2008) Priming in oxytocin cells and in gonadotrophs. Neurochem Res 33:668–677 Leng G, MacGregor DJ (2008) Mathematical modelling in neuroendocrinology. Journal of Neuroendocrinology 20: 713–718 2007 Douglas AJ, Johnstone LE, Leng G (2007) Neuroendocrine mechanisms of change in food intake in pregnancy; A potential role for brain oxytocin. Physiology & Behavior 91:352-365 Leng G, Caquineau C, Ludwig M, Sabatier N (2007) Priming in oxytocin cells and in gonadotrophs. Neurochemical Research. In press Leng G, Onaka T, Caquineau C, Sabatier N, Tobin V, Takayangi Y (2007) Oxytocin and appetite Progress in Brain Research. In press Leng G (2007) Proteomics; inspiring new hypotheses in the vasopressin system Endocrinology 148:3039-3040 Brown CH, Scott V, Ludwig M, Leng G, Bourque CW (2007) Somato-dendritic dynorphin release: orchestrating activity patterns of vasopressin neurons. Biochem Soc Trans. In press Sabatier N, Leng G (2007) Bistability with hysteresis in the activity of vasopressin cells. J Neuroendocrinol 19(2): 95-101 Sabatier N, Rowe I, Leng G (2007) The role of intrahypothalamic release of oxytocin in the regulation of appetite. Biochem Soc Trans. In press
2006 Brown CH, Leng G, Ludwig M, Bourque CW (2006) Endogenous activation of supraoptic nucleus {kappa}-opioid receptors terminates spontaneous phasic bursts in rat magnocellular neurosecretory cells. J Neurophysiol 95(5):3235-3244 Brunton PJ, Sabatier N, Leng G, Russell JA (2006) Suppressed oxytocin neurone responses to immune challenge in late pregnant rats: A role for endogenous opioids. Eur J Neurosci 23(5):1241-1247 Caquineau C, Leng G, Guan XM, Jiang M, Van der Ploeg L, Douglas AJ (2006) Effects of alpha-melanocyte-stimulating hormone on magnocellular oxytocin neurones and their activation at intromission in male rats. J Neuroendocrinol 18(9): 685-691 Johnstone LE, Fong TM, Leng G (2006) Neuronal activation in the hypothalamus and brainstem during feeding in rats. Cell Metabolism 4:313-321 Leng G, Ludwig M (2006) Information processing in the hypothalamus: Peptides and analogue computation. J Neuroendocrinol 18: 379-392 Ludwig M, Leng G (2006) Dendritic peptide release and peptide-dependent behaviours. Nature Reviews Neuroscience 7:126-136 Sabatier N, Leng G (2006) Presynaptic actions of endocannabinoids mediate {alpha}-MSH-induced inhibition of oxytocin cells. Am J Physiol 290(3):R577-R584 Sabatier N, Leng G (2006) Vasopressin and fluid balance- running hard to stand still. In Multidisciplinary Approaches to Theory in Medicine R Paton & L McNamara (eds) Elsevier: pp 353-368
2005 Brown CH, Stern JE, Jackson KLM, Bull PM, Leng G, Russell JA (2005) Morphine withdrawal increases intrinsic excitability in oxytocin cells in morphine-dependent rats. European Journal of Neuroscience 21: 501-512 Johnstone LE, Kumarnsit E, Leng G (2005) Hypothalamic expression of NPY mRNA, vasopressin mRNA and CRF mRNA in response to food restriction and central administration of the orexigenic peptide GHRP-6. Stress 8: 59-67 Leng G, Caquineau C, Sabatier N (2005) Regulation of oxytocin secretion. Vitamins and Hormones 71: 27-58 Ludwig M, Tobin V, Sabatier N, Bull PM, Dayanithi G, Landgraf R., Leng G (2005) Regulation of activity-dependent dendritic vasopressin release from rat supraoptic neurones. Journal of Physiology 564: 515-522 MacGregor DJ, Leng G (2005) Modelling the hypothalamic control of growth hormone secretion. J Neuroendocrinol 17(12):788-803 Russell JA, Leng G (2005) Neuroendocrine Networks. In Integrative Physiology in the Ptoteomics and Post Genomics Age Waltz W (ed) Humana Press New Jersey, pp 67-94
2004 Brown CH, Ludwig M, Leng G (2004) Temporal dissociation of the feedback effects of dendritically co-released peptides on rhythmogenesis in magnocellular neurosecretory cells. Neuroscience 124: 105-111 Brown D, Stephens EA, Smith RG, Li G, Leng G (2004) Estimation of parameters for a mathematical model of growth hormone secretion. Journal of Neuroendocrinology 16: 936-946 Johnstone LE, Leng G, Brown CH (2004) Effects of neurotensin on the organisation of activity in supraoptic nucleus cells in virgin and lactating rats. Journal of Neuroendocrinology 16: 605-611 Leng G, Sabatier N, Reif-Marganiec A, Ludwig M, Sabatier N (2004) Generating quantitatively accurate, but computationally concise, models of single neurons. In Computational Neuroscience: A Comprehensive Approach. Eds J Feng Chapman & Hall/CRC Press pp 185-213 Ludwig M, Leng G (2004) Conditional priming of dendritic neuropeptide release. In Dendritic Secretion Ludwig M (ed) Springer Verlag MacGregor DJ, Leng G, Brown D. (2004) Modelling the GH release system. In Paton R, Bolouri H, Holcombe M, Parish JH, Tateson R, eds. Computation in Cells and Tissues, Springer, Berlin Heidelberg, pp 227-250 Sabatier N, Brown CH, Ludwig M, Leng G (2004) Phasic spike patterning in rat supraoptic neurones in vivo and in vitro. Journal of Physiology 558: 161-80 Scullion S Brown DA, Leng G (2004) Modelling the pituitary response to luteinising hormone-releasing hormone. Journal of Neuroendocrinology 16: 265-271 Srisawat R, Bishop VR, Bull PM, Douglas AJ, Russell JA, Ludwig M, Leng G (2004) Regulation of neuronal nitric oxide synthase (nNOS) mRNA expression in the magnocellular neurosecretory system. Neuroscience Letters 369: 191-196
2003 Kumarnsit E, Johnstone LE, Leng G (2003) Actions of neuropeptide Y and growth hormone secretagogues in the arcuate nucleus and ventromedial hypothalamic nucleus. European Journal of Neuroscience 17: 937-944 Leng G, Sabatier N, Douglas AJ (2003) Oxytocin released from magnocellular dendrites: A potential modulator of alpha-MSH behavioural actions? Annals of the New York Academy of Sciences 994: 218-224 Russell JA, Leng G, Douglas AJ (2003) The magnocellular oxytocin system. The fount of maternity: adaptations in pregnancy. Frontiers in Neuroendocrinology 24: 27-61 Sabatier N, Caquineau C, Bull P, Douglas AJ, Dayanithi G, Guan XM, Jiang M, Van der Ploeg L, Leng G (2003) Alpha-melanocyte-stimulating hormone stimulates oxytocin release from the dendrites of hypothalamic neurons while inhibiting oxytocin release from their terminals in the neurohypophysis. Journal of Neuroscience 23: 10351-10358 Widmer H, Ludwig M, Bancel F, Leng G, & Dayanithi G (2003) Neurosteroid regulation of oxytocin and vasopressin release from the rat supraoptic nucleus. Journal of Physiology 548: 233-244 2002 Douglas AJ, Leng G, Russell JA (2002) The importance of oxytocin mechanisms in the control of mouse parturition. Reproduction 123: 543-552 Douglas AJ, Bicknell RJ, Leng G, Russell JA, Meddle SL (2002) Beta-endorphin cells in the arcuate nucleus: projections to the supraoptic nucleus and changes in expression during pregnancy and parturition. Journal of Neuroendocrinology 14 :768-777 Ludwig M, Sabatier N, Bull PM, Landgraf R, Dayanithi G, Leng G (2002) Intracellular calcium stores regulate activity-dependent neuropeptide release from dendrites. Nature 418: 85-89 Ludwig M, Sabatier N, Dayanithi G, Russell JA, Leng G (2002) The active role of dendrites in the regulation of magnocellular neurosecretory cell behaviour. Prog Brain Res 139: 247-256 2001 Bailey ART, Gilliver L, Leng G, Smith RG (2001) Central actions of the nonpeptide growth hormone secretagogue GHS-25. Endocrine 14: 15-19 Doi N, Brown CH, Cohen HD, Leng G, Russell JA (2001) Effects of the endogenous opioid peptide, endomorphin 1, on supraoptic nucleus oxytocin and vasopressin neurones in vivo and in vitro. British Journal of Pharmacology 132: 1136-1144 Douglas AJ, Scullion S, Antonijevic IA, Brown D, Russell JA, Leng G (2001) Uterine contractile activity stimulates supraoptic neurons in term pregnant rats via a noradrenergic pathway. Endocrinology 142: 633-644 Leng G, Ludwig M, Scullion S, Brown CH, Bull PM, Currie J, Verbalis JG, Blackburn-Munro R, Onaka T, Feng J & Russell JA (2001) Responses of magnocellular neurons to osmotic stimulation involves co-activation of excitatory and inhibitory input: an experimental and theoretical analysis. Journal of Neuroscience 21: 6967-6977 1997 Leng G, Brown D (1997) The origins and significance of pulsality in hormone secretion from the pituitary. Journal of Neuroendocrinology 9: 419-513
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| ___________________________________________ Designed and published by Marianne Eastwood (m.eastwood@ed.ac.uk) © The University of Edinburgh .Updated 9 July 2008 |
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