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Imaging of synaptic vesicle turnover using FM4-64 Model mammalian morphogenesis - real renal collecting duct growing in vitro Model mammalian morphogenesis - computer model of collecting duct 'growing' in silico Stripes in the cornea of a mouse F-actin cytoskeleton in bovine chondrocyte cells TO-PRO3 labelling of DNA in dividing cells Actin and tubulin cytoskeletal labelling of cells Rat retina flat mount - astrocyte (red) and artery (green) interaction with vein Whole mount E10.5 embryo Detail from adult testes - PI nuclear counterstain

    Rory Duncan


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Dr Rory Duncan

Dr Rory Duncan
Wellcome Trust Research Career Development Fellow, University of Edinburgh

Hugh Robson Building, Edinburgh EH8 9XD

Tel: +44(0)131 650 2864
 Email: rory.duncan@ed.ac.uk
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Personal Profile

  • BSc in Genetics, University of Aberdeen
  • PhD, University of Edinburgh
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Research

We are interested in the proteins which are involved in regulated exocytosis. Our principal approaches combine advanced imaging spectroscopic techniques with molecular and cell biology.

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Funding

  • The Wellcome Trust
  • EPSRC
  • Diabetes UK
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Team Members

  • Carolyn Brechin (visiting from Alastair Aiken’s group)
  • Claire Medine
  • David Moulton
  • Colin Rickman
  • Raniska Tente
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Collaborations

  • Axel Bergmann, Becker and Hickl GmbH
  • Luke Chamberlain, University of Glasgow
  • Enrico Gratton, University of Illinois
  • James Ross (University of Edinbugh)
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Recent Publications

2007

Medine CN, Rickman C, Chamberlain LH, Duncan RR (2007) Munc18-1 prevents the formation of ectopic SNARE complexes in living cells. Journal of Cell Science 120: 4407-4415

Valkonen M, Kalkman ER, Saloheimo M, Penttila M, Read ND, Duncan RR (2007) Spatially segregated SNARE protein interactions in living fungal cells. J Biol Chem 282(31):22775-22785

Medine CN, McDonald A, Bergmann A, Duncan RR (2007) Time-correlated single photon counting FLIM: some considerations for physiologists. Microsc Res Tech 70(5):420-425

Rickman C, Medine CN, Bergmann A, Duncan RR (2007) Functionally and spatially distinct modes of munc18-syntaxin 1 interaction. Journal of Biological Chemistry 282:12097-12103

2006

Bergmann A, Duncan RR (2006) Biological Application of FLIM by TCSPC. Annual Reviews in Fluorescence (In press)

2004

Duncan RR, Bergmann A, Cousin MA, Apps DK, Shipston MJ (2004) Multi-dimensional time-correlated single photon counting (TCSPC) fluorescence lifetime imaging microscopy (FLIM) to detect FRET in cells. J Microsc 215: 1-12

2003

Duncan RR, Greaves J, Wiegand UK, Matskevich I, Bodammer G, Apps DK, Shipston MJ, Chow RH (2003) Functional and spatial segregation of secretory vesicle pools according to their age. Nature 422: 176-180

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Designed and published by Marianne Eastwood (m.eastwood@ed.ac.uk)
© The University of Edinburgh
March 2008